Organ-on-chip technology leverages fluid behavior and phenomena at the microscale to better mimic human physiology in-vitro. Although less complex than actual organs, this simplicity provides a fundamental platform to study tissue and disease.
Specifically, we are interested in applying granular hydrogels (via microfluidic droplet generation) with dynamic flow to create a supportive culture environment. Fluidic perfusion paired with a granular scaffold should increase nutrient contact and waste removal, while providing a support structure.
We are interested in exploring how flow impacts islet culture systems in a perfusable granular scaffold.
