To generate biorhythms-on-chip, our lab develops microfluidic devices to control a dynamic profile of biomolecular compositions and apply the dynamic flow profile to cell culture.

We are currently working with the microfluidic design of oscillators that can convert two constant flow inputs into an alternating flow output. We are aiming to achieve scalable device fabrication process and parallelizable complex fluidic control within an integrated microfluidic system.

Video: an oscillator oscillating between two colored inflows.
Video: multiple oscillators on the same chip with synchronized oscillations between two colored inflows. (speed x 4)

In the future, we are aiming to generate a device with three target functionality:

(1) Versatility: production of various flow profiles

(2) Adoptability: low operation complexity

(3) Parallelizability: synchronization of parallel experiments